COLOSSUSAdvancing a precision medicine paradigm in metastatic colorectal cancer
COLOSSUS is an EU-funded H2020 project that aims to provide new and more effective ways to classify patients with a specific type of colorectal cancer (microsatellite stable RAS mutant metastatic colorectal cancer or MSS RAS mt mCRC) and to develop better treatments for them. Our ultimate goal is to deliver a personalised medicine approach for patients with MSS RAS mt mCRC that is currently not available. Pintail are responsible for project administration, in support of the Coordinator (RCSI). We also work with the team on the exploitation and dissemination of project results.
STARSTEMShedding new light on regenerative medicine
STARSTEM is an innovative project funded under the European Union’s Horizon 2020 scheme. The project is poised to revolutionise stem cell therapy by providing unprecedented understanding about how these therapies actually work. STARSTEM are using fundamental advances in the physics of imaging to validate stem cell treatments for arthritis. Pintail are working with STARSTEM on the dissemination and exploitation of project results. We also help guide the administrative and financial management of the project.
NoHoWResearch in weight loss maintenance
We know a lot about how to lose weight but not a lot about how to maintain weight loss. NoHoW will develop evidence-based ICT tools for weight loss maintenance, including mobile apps, web-based tools and other technologies (activity trackers, smart scales, etc.). The tools will be tested in real world settings in Denmark, Portugal and the United Kingdom, and commercial programmes for weight loss maintenance will be developed using the project results. Pintail will provide administrative support to the project Coordinator, Prof. Berit Heitmann, Director for Research and Education at the Institute for Preventive Medicine, Region Hovesdstaden (Denmark), as well as contribute exploitation and dissemination expertise.
ADIPOA-2Stem cell research for joint health
ADIPOA-2 is developing a novel stem cell therapy to treat osteoarthritis, and will deliver a large-scale clinical trial in regenerative medicine for the treatment of knee osteoarthritis. Pintail has wide experience in regenerative medicine projects, and has been involved in ADIPOA-2 from the beginning, providing support for all stages of the proposal writing process. We are now active partners in the project, supporting the coordinator in the management of the project, as well as dissemination and exploitation.
EuroFITEuropean Fans in Training
The goal of EuroFIT is to harness the ‘love of the game’ to engage football fans in health-promoting lifestyle changes through their loyalty and attachment to their clubs. EuroFIT will engage men through their connection with their clubs to make sustainable improvements in their diet, activity, and physical fitness. This innovative men’s health project, coordinated by Prof. Sally Wyke at the University of Glasgow, is an extension of the successful Scottish programme Football Fans in Training. In addition to rolling out the Football Fans in Training activities across Europe, the EuroFIT project will be developing new devices to help monitor training and sedentary periods of users. Pintail will be involved in the management and dissemination aspects of the project.
PanCareLIFELife after childhood cancer
The goal of PanCareLIFE is that survivors of cancer diagnosed before age 25 should enjoy the same quality of life and opportunities as their peers who have not had cancer. Using observational studies and molecular genetic investigations PanCareLIFE will investigate late effects that impact fertility and hearing impairment (ototoxicity), and will assess health-related quality of life. Information from PanCareLIFE’s studies will be incorporated into new guidelines for fertility preservation. The project is coordinated by Dr. Peter Kaatsch at the University Medical Center of Johannes Gutenberg University, Mainz and the Boyne Research Institute, Ireland. Pintail will provide project management support and dissemination expertise.
MERLINDeveloping stem cell-based therapies
MERLIN explores exciting new opportunities in stromal cell therapy R&D, while making important contributions to the treatment of currently intractable inflammatory and immune mediated liver diseases. Merlin will establish the action of Mesenchymal Stromal Cells (MSC) in an archetypal inflammatory liver disease primary sclerosing cholangitis (PSC) in order to develop an entirely new treatment option for patients, presently facing a disease devoid of effective medical care. MERLIN will employ novel, non-bead based methods of cell sorting to purify mesenchymal stem cells for therapeutic use in the project. Pintail will help the team with project management and dissemination activities, as well as deliver a customised, secure, cloud-based data management platform, based on our ‘StudyVault’ platform, to manage and share data generated by the consortium.
MErCuRICCombinatorial therapy for colorectal cancer
MErCuRIC will develop a novel combinatorial therapy for colorectal cancer that is targeted to specific patient sub-groups. The seven-year project is coordinated by Dr. Sandra Van Schaeybroeck of Queen’s University Belfast. Pintail has been involved in a number of cancer related projects over the years and will support the coordinator in project administration and dissemination efforts.
VISICORTImproving the success rate of corneal transplants
VISICORT, coordinated by Prof. Matt Griffin at NUI, Galway, is a multidisciplinary EU project which will study adverse immune responses to corneal transplantation to pioneer new understandings of immune responses to tissue transplants and implants. Pintail has been involved in VISICORT since its inception, contributing to all aspects of the proposal process. We are now active partners in the project, supporting the management of the project, as well as dissemination and exploitation.
NephstromNovel stromal cell therapy for diabetic kidney disease
Nephstrom builds on exciting results from our REDDSTAR project, to carry out a first-in-man Phase Ib / IIa clinical trial of our unique Cyndacel M-therapeutic in the treatment of chronic diabetic kidney disease. In order to underpin future routine clinical use, NEPHSTROM will develop and validate a new combined manufacturing platform That Improves the consistency and Reduces the cost of the MSC therapeutic. This will involve the development of the first “closed-automated” GMP method of MSC isolation and expansion, and the creation of a network of four European cell production centers.
NOMADThe NOMAD Laboratory: A European Centre of Excellence
NOMAD is a European Centre of Excellence that brings together physicists, chemists, materials, and computer scientists, and industry to develop a Materials Encyclopaedia and advanced tools for Big-Data Analytics to facilitate the discovery, creation and utilisation of new materials. The Centre is Coordinated by Prof. Scheffler of the Max Planck Society’s Fritz Haber Institute in Berlin, and includes seven other leading materials science centres plus four super-computing centres. Pintail will provide administrative support to the project Coordinator, as well as contribute exploitation and dissemination expertise.
AutostemProduction line for stem cell manufacture
AUTOSTEM is developing a closed, automated, sterile pipeline for largescale production of therapeutic stem cells. This will enable lower-cost, higher-quality and more consistent stem cells to be produced, ultimately helping patients to benefit from new stem cell therapies. Pintail joined the team at the proposal stage and is now a partner, providing support to the Coordinator Dr Mary Murphy (NUIG) in respect of project management, dissemination and exploitation.
DEXLIFEDiet Exercise and Life
DEXLIFE (2012 – 2015) was an innovative diabetes research project, coordinated by the Steno Diabetes Centre in Copenhagen. The project generated new knowledge about diabetes biomarkers and personalised interventions, that provides health care providers and policy makers with a sound basis for future health policy, diabetes supports and interventions. Pintail provided EU expertise, administrative support and dissemination/exploitation expertise.
AngioPredictPersonalised medicine for patients with metastatic colorectal cancer
Pintail was invited to join this cancer research project by RCSI at the start of the negotiation phase. We worked closely with the coordinator throughout the demanding negotiation process through to the project kickoff in February 2012. We currently provide administrative support and dissemination expertise for the project.
In-MINDDINnovative, Midlife INtervention for Dementia Deterrence
In-MINDD is a social innovation project, coordinated by Dr. Kate Irving of DCU, aimed at reducing the risk of developing dementia in later life through intervention during middle age. Pintail was involved throughout the proposal and negotiation processes, and will provide management support, as well as dissemination expertise, once the project begins in late 2012.
EU-WISE is an FP7-funded project to better understand capabilities, resources, and changes in health related practices in community and cultural context across Europe. The project has a particular focus on self-management of chronic, long-term diseases (e.g. diabetes), and on the roles and relationships of patients, families, professional carers, GPs and clinicians. EU-WISE is coordinated by Prof. Anne Rogers at the University of Southampton. Pintail joined the active project in 2012 to provide project management and dissemination expertise.
RestoreHealth of migrants
RESTORE (2011 – 2015), coordinated by Dr. Anne MacFarlane of the University of Limerick, aimed to optimise the delivery of primary healthcare to migrants in Europe, addressing the “know-do” gap between the implementation of evidence-based solutions to language and cultural barriers into routine clinical practice. In addition, the project focused on the translational gap between health services research and wider health related policy. Pintail was invited to join the project in the negotiation phase and provided EU expertise, administrative support and dissemination/exploitation expertise during the project.
GlycoHITGlycomics by High throughput Integrated Technologies
Pintail worked with the AGRC at NUI Galway to submit this 16-partner glycomics/cancer proposal (with Chinese, Japanese and US partners) to the 2010 FP7 Health call. We now support the Galway team in dissemination, consortium management, reporting and budget control. We’re now working with the AGRC on a new proposal.
APO-DecideSystems Medicine to Deliver Personalised Medicine for Colorectal Cancer
APO-DECIDE (2012 – 2014), coordinated by Prof. Jochen Prehn of the Royal College of Surgeons in Ireland, was an FP7-funded, SME-focused project that explored the potential of a systems-based analysis of apoptosis signalling pathways to deliver new prognostic and predictive biomarkers for the management of advanced colorectal cancer, and new tools for patient stratification for therapies targeting apoptosis deficiencies in cancer. Pintail worked with the consortium from the proposal phase, providing EU expertise, during the negotiation phase , and administrative support and dissemination/exploitation expertise during the project .
PurstemLarge-scale manufacture of stem cells for therapeutic use
PurStem (2007 – 2012), led by Prof. Frank Barry at NUI Galway, advanced the state-of-the-art in the large-scale manufacture of stem cells for therapeutic use. Pintail were involved in project administration, providing extensive EU expertise, and led dissemination and communication activities. By the end of the project, a rigorous protocol for the isolation and culture of MSCs had been developed and validated, and our understanding of basic stem cell biology was advanced.
Pintail worked with the Italian Ministry of Fine Arts on Linked Heritage (2011 – 2013), the fifth in a series of successful digital cultural heritage proposals on which Pintail has collaborated. The project contributed large volumes of new content to Europeana, focusing on content quality, metadata, re-use potential and uniqueness, as well as improving search, retrieval and use of Europeana content. Pintail’s project role was primarily technical writing, quality assurance, expert consultancy and technology support – a partner company in Italy provides coordination support.
CULTURACultivating understanding and research through adaptivity
Pintail was invited to join the CULTURA proposal team by the coordinator in TCD, and supported them in the formulation of an excellent ICT-meets-digital-humanities proposal and throughout the negotiation process. Since the kick-off we have focused on internal evaluation, reporting and administration and intellectual property management. Cultura ended in spring 2014, receiving a rating of ‘excellent’ at the final review.
RUBICONRobotics UBIquitous COgnitive Network
RUBICON (2011 – 2014), coordinated by Prof. Gregory O’Hare of UCD, created a self-learning robotic ecology, which was was applied to Ambient Assisted Living (AAL) and hospital transport scenarios. Pintail was involved in all parts of the proposal process for the project, and were active partners in the project, offering management support, dissemination, evaluation and exploitation planning.
REDDSTARRepair of Diabetic Damage by Stromal Cell Administration
Pintail joined the REDDSTAR team during the proposal phase and worked with the coordinator, Prof. Timothy O’Brien of NUI Galway, and members of Orbsen Therapeutics Limited, to ensure a smooth negotiation process. The project builds on work carried out during the PurStem project, where Pintail was also a partner. Pintail will contribute to the project R&D by developing a customized data management platform, as well as providing management support and dissemination/exploitation expertise. We are looking forward to working with the team when the project gets underway in late 2012.
SLANDAILEmpowering emergency response using social media
Project Slándáil (2014 – 2017) was a collaboration of emergency operatives, academics, ethics- and security-oriented NGO and four SMEs, coordinated by Prof Khurshid Ahmad of Trinity College Dublin. Their common purpose was to make maximum ethical use of the information available in the social media to enhance the performance of emergency management systems. Pintail was involved in the project since its inception, contributing to all aspects of the proposal process, as well as supporting project management, dissemination and exploitation once funded.