Congratulations to STARSTEM‘s University of Cambridge team of Will Hotham and Frances Henson on their recent review paper, ‘The use of large animals to facilitate the process of MSC going from laboratory to patient—‘bench to bedside’‘. The paper was recently published in the International Journal of Cell Biology and Toxicology.
The review illustrates how mesenchymal stem cells (MSC) have been translated to man through large animal models. Two very different examples were used— myocardial disease (where one gold standard large animal model has been used in one species to show efficacy) and osteoarthritis (where multiple species and models have been used). Used appropriately, large animal models allow clinically relevant assessments of safety, efficacy and dosing prior to clinical trials and continue to provide a research platform that can be used to evaluate the value of cell-based therapies.
Read more here. Find the full paper online or download the PDF.
STARSTEM has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 761214. The material presented and views expressed here are the responsibility of the author(s) only. The EU Commission takes no responsibility for any use made of the information set out.